Spatio-temporal information in cultured neuronal networks

00:00 20-06-2007

Cultured neuronal networks generate spontaneous activity in the form of synchronized bursting events (SBEs) - short time events during which most of the recorded neurons fire rapidly. Each neuron in the SBE has its own temporal firing rate pattern. It has been shown that a large network can exhibit several SBE sub-groups, each with its own characteristic spatio-temporal

pattern of activity. Thus, the partitioning of SBEs into

sub-groups can serve as a template for long-term memory. In this

presentation I will address the question: what distinguishes one sub-group of SBEs from another and how is the spatio-temporal information carried out? I will show that in uniformly random networks, in each SBE type the neurons fire at different delays relative to one another and that in different SBEs the firing rate function of each neuron remains relatively the same. By culturing networks with a specially designed morphology, we can enforce the neurons to generate different spike trains as a reaction to the different burst motifs.

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