Faculty & staff

• Protein engineering
• Blood coagulation

• Selected topics in chemistry and biology
• The anatomy and the physiology of the human body
• Seminar in selected topics in bio-engineering
• Topics in chemistry and biology for technology management
• Topics in genetics
• Introduction to modern biology

Ph.D. students

2010-2015, Lihie Levin,MD study of the mechanism behind integrin activation: The inside-out signaling, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Israel (in collaboration with Prof. Menachem Gutman and Dr. Yossi Tsfadia).

M.Sc. students

2011-2014, Hagit Gdalia, Molecular dynamics study of thrombin equilibrium, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Israel (in collaboration with Dr. Yossi Tsfadia).

2008-2010, Ehud Zelzion, The effect of a single S-S bond disruption on the conformation of integrin aIIb3, a molecular dynamics study, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Israel (in collaboration with Prof. Menachem Gutman).

2008-2009, Wissam Mansour, A novel mutation of a highly conserved residue of integrin aIIb, Asn2Asp, causes Glanzmann thrombasthenia, Sackler School of Medicine, Tel-Aviv University (in collaboration with Prof. Uri Seligsohn).

Undergraduate students:

2014-2015, Daniel Dekalo, Computational design of protein-based ligands for cell integrins, Bioengineering Department, Faculty of Engineering, HIT.

2014-2015, Ronen Itkin and Aviram Bezalel, A computational model of the thrombin protein using molecular dynamics simulation, Bioengineering Department, Faculty of Engineering, HIT.

1. O. Cohen, Y. Einav, Y. Cohen, A. Karasik, S. Ferber
   Implantation of rat insulinoma cell line into cyclosporine treated rats
   Effect of the in vivo environment on beta-cell specific gene expression
   Transplantation, 69(7), 2000 (1464-1470)
2. S. Ferber, A. Halkin, H. Cohen, I. Ber, Y. Einav, I. Goldberg, I. Barshack, R.Seijffers, J. Kopolovic, N. Kaiser, A. Karasik
   Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in
   liver and ameliorates streptozotocin-induced hyperglycemia
   Nature Medicine, 6(5), 2000 (568-572)
3. Y. Einav, E. Shistik, M. Shenfeld, A.H. Simons, D.W. Melton, D. Canaani
   Replication and episomal maintenance of Epstein-Burr virus-based vectors in mouse embryo fibroblasts enable synthetic lethality screens
   Molecular Cancer Therapeutics, 2, 2003 (1121-1128)
4. Y. Einav, R. Agami, D. Canaani
   shRNA-mediated RNA interference as a tool for genetic synthetic
   lethality screening in mouse embryo fibroblasts
   Federation of European Biochemical Societies (FEBS) Letters, 579, 2005 (199-202)
5. B. Shenkman, Y. Einav, O. Salomon, D. Varon, N. Savion
   Testing agonist-induced platelet aggregation by the Impact-R
   [Cone and plate(let) analyzer (CPA)]
   Platelets, 19(6), 2008 (440-446)
6. B. Shenkman, S. Matetzky, P. Fefer, H. Hod, Y. Einav, A. Lubetsky, D. Varon, N. Savion
   Variable responsiveness to clopidogrel and aspirin among patients with acute coronary syndrome as assessed by platelet function tests
   Thrombosis Research, 122, 2008 (336-345)
7. W. Mansour, Y. Einav, H. Hauschner, A. Koren, U. Seligsohn, N. Rosenberg
   An αΠb mutation in patients with Glanzmann thrombasthenia located in the N-terminus
   of blade1 of the β-propeller (Asn2Asp) disrupts a calcium binding site in blade 6
   J. of Thrombosis and Haemostasis, 9(1), 2011 (192-200)
8. M. Misgav, B. Shenkman, I. Budnik, Y. Einav, U. Martinowitz
   Differential roles of fibrinogen and von Willebrand factor on clot formation and
   platelet adhesion in reconstituted and immune thrombocytopenia
   Anesthesia & Analgesia, 112(5), 2011 (1034-1040)
9. R. Mor-Cohen, N. Rosenberg, Y. Einav, E. Zelzion, M. Landau, W. Mansour, Y. Averbukh, U. Seligsohn
   Unique disulfide bonds in the Epidermal Growth Factor (EGF) domains of β3 affect the structure and function of αΠbβ3 and αvβ3 integrins in a different manner
   J. of Biological Chemistry, 287, 2012 (8879-8891)
10. B. Shenkman, T. Livnat, A. Lubetsky, I. Tamarin, I. Budnik, Y. Einav, U. Martinowitz
    The in vitro effect of fibrinogen, factor XIII and thrombin-activatable
    fibrinolysis inhibitor on clot formation and susceptibility to tissue
    plasminogen activator-induced fibrinolysis in hemodilution model
    Blood Coagulation and Fibrinolysis, 23(5), 2012 (370-378)
11. B. Shenkman, T. Livnat, M. Misgav, I. Budnik, Y. Einav, U. Martinowitz
    The in vivo effect of fibrinogen and factor XIII on clot formation and fibrinolysis in Glanzmann's Thrombasthenia
    Platelets, 23(8), 2012 (604-610)
12. B. Shenkman, T. Livnat, I. Budnik, I. Tamarin, Y. Einav, U. Martinowitz
    Plasma tissue-type plasminogen activator increases fibrinolytic activity of exogenous urokinase-type plasminogen activator
    Blood Coagulation and Fibrinolysis, 23(8), 2012 (729-733)
13. L. Levin, E. Zelzion, E. Nachliel, M. Gutman, Y. Tsfadia, Y. Einav
    A single disulfide bond disruption in the β3 integrin subunit promotes Thiol/Disulfide exchange, a molecular dynamics study
    PloS One, 8(3), 2013: e59175 (10 pages)
14. G. Barnhart-Magen, V. Gotlib, R. Marilus, Y. Einav
    Differential diagnostics of Thalassemia minor by artificial neural networks model
    J. of Clinical Laboratory Analysis, 27, 2013 (481-486)
15. B. Shenkman, Y. Einav, T. Livnat, I. Budnik, U. Martinowitz
    In vitro evaluation of clot quality and stability in a model of severe thrombocytopenia: Effect of fibrinogen, factor XIII and thrombinactivatable fibrinolysis inhibitor
    Blood Transfusion, 12(1), 2014 (78-84)
16. B. Shenkman, Y. Einav
    Thrombotic thrombocytopenic purpura and other thrombotic microangiopathic
    hemolytic anemias: Diagnosis and classification
    Autoimmunity Reviews, 13(4-5), 2014 (584-586)
17. W. Mansour, H. Hauschner, U. Seligsohn, N. Rosenberg, Y. Einav
    Natural and artificial mutations in αΠb integrin lead to a structural deformation of a calcium-binding site
    Protein J., 33(5), 2014 (474-483)
18. B. Shenkman, Y. Einav, T. Livnat, I. Budnik, U. Martinowitz
    Rotation thromboelastometry analysis of clot formation and fibrinolysis in severe thrombocytopenia: Effect of fibrinogen, activated prothrombin complex concentrate, and thrombin- activatable fibrinolysis inhibitor
    Int'l. J. of Laboratory Hematology, 37(4), 2015 (521-529)
19. B. Shenkman, I. Budnik, Y. Einav, H. Hauschner, M. Andrejchin, U. Martinowitz
    Model of trauma-induced coagulopathy including hemodilution, fibrinolysis, acidosis, and hypothermia: Impact on blood coagulation and platelet function
    J. of Trauma and Acute Care Surgery, 82(2), 2017 (287-292)
20. H. Gdalya, E. Nachliel, M. Gutman, Y. Einav, Y. Tsfadia
    The translocation of Na+ ion inside human thrombin accounts for the activation of the enzyme
    Israel J. of Chemistry, 57, 2017 (413-423)
21. H. Friman, I. Halabi, A. Ochayon, I. Banner, B. Shalom-Tuchin, Y. Einav
    Environmental education for the community
    Int'l. J. of Environmental Science, 2, 2017 (166-170)
22. H. Friman, I. Halbi, A. Ochayon, I. Banner, B. Shalom-Tuchin, Y. Einav
    Multidisciplinary course at environmental science
    Int'l. J. of Recent Scientific Research, 8(8), 2017 (19076-19079)
23. H. Friman, Y. Sitbon, I. Banner, Y. Einav
    Environmental Education without words for the next generation
    Int'l. J. of Latest Research in Engineering and Technology (IJLRET), 4(2), 2018 (36-40)
24. H. Friman, Y. Sitbon, I. Banner, Y. Einav
    Environmental engineering education overcome the language barrier
    Int'l. J. of Environmental Science, 3, 2018 (62-67)
25. H. Friman, Y. Sitbon, I Banner, T. Shauli, Y. Einav
    Renewable energy, ecology and environment to Arabic pupils using a creative "Hands On" approach
    Environments, 5, 2018 (66 – 12 pages)
26. T. Shlamkovich, L. Aharon, D. Koslawsky, Y. Einav, N. Papo
    Targeting the Tie2-av3 integrin axis with bi-specific reagents for the inhibition of Angiogenesis
    BMC Biology, 16(1):92, 2018 (18 pages)
    [https://doi.org/10.1186/s12915-018-0557-9]
27. Y. Zur, L. Rosenfeld, C.A. Keshelman, N. Dalal, G. Guterman-Ram, A. Orenbuch, Y. Einav, N. Levaot, N. Papo
    A dual-specific macrophage colony-stimulating factor antagonist of c-FMS and avβ3 integrin for osteoporosis therapy
    PLOS Biology, 16(8), 2018, e2002979
    [doi: 10.1371/journal.pbio.2002979]
28. H. Friman, Y. Sitbon, I Banner, T. Shauli, Y. Einav
    Environmental and sustainability studies for pupils in elementary Arabic school
    Int'l. J. of Innovation, Management and Technology 9(6), 2018 (266-270)
    * Publication on teaching methodology
29. I. Budnik, B. Shenkman, O. Morozova, J. Andreichyn, Y. Einav
    Correction of coagulopathy in thrombocytopenia and Glanzmann thrombasthenia models by fibrinogen and factor XIII as assessed by thromboelastometry
    Pathophysiology, 25, 2018 (347-351)
30. I.A. Budnik, O.Morozova , A.A. Tsymbal, B.Shenkman, Y. Einav
    Effects of tranexamic acid, factor XIII, and fibrinogen on clot formation and lysis in the model of hyperfibrinolysis induced by tissue- vs urokinase-type plasminogen activator
    Gematologiya i Transfusiologiya (Russian J. of Hematology and Transfusiology)
    63(1), 2018 (55-64) [in Russian]
31. I. Budnik, B. Shenkman, O. Morozova, Y. Einav
    Thromboelastometry assessment of the effects of fibrinogen, activated prothrombin complex concentrate, and tranexamic acid on clot formation and fibrinolysis in a model of trauma-induced coagulopathy
    European J. of Trauma and Emergency Surgery 2 December 2019
32. O. Morozova, D. Morozov, D. Pervouchine, Y. Einav, D. Lakomova, N. Zakharova, L. Severgina, L. Maltseva, I. Budnik
    Urinary biomarkers of latent inflammation and fibrosis in children with vesicoureteral reflux
    International Urology and Nephrology 4 December 2019

1. N. Rosenberg, Y. Einav, B. Shenkman
   Autoimmune thrombocytopenic purpura (Part XIII, 543-546)
   In: Diagnostic Criteria in Autoimmune Diseases
   Y. Shoenfeld, R. Cervera, M.E. Gershwin (eds.)
   XIV, 2008 (598 pages)
   [ISBN: 978-1-60327-427-2]
2. B. Shenkman, Y. Einav, O. Salomon
   Thrombotic thrombocytopenic purpura and other thrombotic
   microangiopathic hemolytic anemias (Part XIII, 547-550)
   In: Diagnostic Criteria in Autoimmune Diseases
   Y. Shoenfeld, R. Cervera, M.E. Gershwin (eds.)
   XIV, 2008 (598 pages)
   [ISBN: 978-1-60327-427-2]
3. B. Shenkman, N. Rosenberg, Y. Einav
   Platelet autoantibodies
   in: Autoantibodies (3rd edition)
   Yehuda Shoenfeld, Pier Luigi Meroni, M. Eric Gershwin (eds.)
   Elsevier B.V., 2014, Ch.61 (519-525)
   [ISBN-13: 9780444563781]